01 - In a large skillet over medium-high heat, cook the ground beef with salt, pepper, smoked paprika, and garlic powder. Break up the meat and stir occasionally until browned and cooked through, about 7–8 minutes. Drain excess fat if needed.
02 - While the beef is cooking, whisk together the mayonnaise, ketchup, mustard, pickle relish, vinegar, smoked paprika, salt, and pepper in a small bowl. Set aside.
03 - Divide the chopped romaine lettuce among four large bowls.
04 - Top each bowl with equal portions of cooked ground beef, cherry tomatoes, cheddar cheese, red onion, pickle slices, and diced avocado.
05 - Drizzle each bowl with burger sauce just before serving. Serve immediately.